Vitamin E Prevents Diabetes Complications

Vitamin E is a safe and effective antioxidant Liu. Diabetic patients taking large doses of vitamin E (400-1000 mg daily), although there is no hypoglycemic effect, but can limit protein non-enzymatic glycation, reduce lipid peroxidation, scavenging free radicals, improve platelet and endothelial function, correct fat Metabolic disorders, and thus play a role in the prevention and treatment of chronic complications of diabetes. Professor Wang Fuzhen of the Second Military Medical University pointed out at the seminar on vitamin E and health held recently that the dose of vitamin E used in clinical practice is too small and its effect is limited.

Chronic complications of diabetes are major causes of disability and death in patients with diabetes. Preventing chronic complications and improving the quality of life is an important part of diabetes treatment. Wang Fudi said that in recent years, glucose was found to activate protein kinase C (PKC). The activated PKC causes a series of related pathological changes in diabetes, such as vascular permeability, contractility, hemorheology and gene expression. Animal experiments have shown that large doses of vitamin B can reduce PKC activity and thus improve glomerular and retinal function in diabetic mice. Due to the toxic effects of long-term hyperglycemia, there are excessive non-enzymatic glycations of various proteins in diabetics. These non-enzymatic glycation products are closely related to diabetic vascular lesions, renal lesions, lipid metabolism disorders, neuropathy, and ocular lesions. Some scholars have treated diabetic rats with high-dose vitamin E of 1000 mg/kg body weight, which significantly reduced the level of HbA1c. Vitamin E as a strong oxidant may interfere with the oxidation of monosaccharides, weakening the covalent attachment of sugars and plasma, thereby limiting the non-enzymatic glycosylation of proteins.

The free radical activity of diabetics is enhanced and plasma lipid peroxide levels are increased. Vitamin E is an important free radical scavenger. It can provide active hydrogen atoms to combine with free radicals to stabilize them, and can inhibit the peroxidation of unsaturated fatty acids on biofilms. Abnormal platelet and endothelial cell function can contribute to the development of diabetic vascular disease. However, the use of 400-1000 mg of vitamin E per day for the treatment of insulin-dependent diabetes found that the patient's platelet aggregation function was significantly reduced.