J Leukocyte Biol: Scientists develop new autoimmune disease therapies

Release date: 2016-05-06

In a research paper published in the journal Journal of Leukocyte Biology , researchers from the University of Geneva in Switzerland found that a special enzyme called a salt-inducing kinase may help to effectively contain autoimmune diseases. Uncontrolled inflammatory manifestations; the researchers point out that by inhibiting the effects of salt-inducing kinases, the production of inflammatory molecules in specific immune cells can be significantly restricted, which confirms the increased local anti-inflammatory IL-10 by human immune cells. A concept of treating diseases at a level.

Researcher Dr. Maria Stella Lombardi said that we will continue to conduct in-depth research in the later stages of the laboratory and demonstrate the potential therapeutic significance of using salt-induced kinases to treat immune system-mediated inflammatory diseases; of course, new potentials developed using this approach, And a drug-like inhibitor of choice may help the researcher to conduct a later study of animal models of chronic inflammatory and autoimmune diseases.

In the article, researchers used two structurally unrelated small molecular salt-inducing kinase inhibitors, or a study called RNAi interference technology, found that salt-induced kinase inhibitors can slow down the body's pro-inflammatory cytokines. (TNF-α and IL-12) were produced, and the researchers also found that the use of this method can also increase the secretion of the anti-inflammatory factor IL-10 in cultured human monocytes, macrophages and dendritic cells.

Finally, researcher John Wherry said that inflammatory disorders are one of the many diseases we have found in the clinic, but different inflammatory diseases are not the same in terms of clinical manifestations and pathogenesis. This study is a new potential for later development. The treatment or combination of other different therapies to provide effective ideas for the treatment of inflammatory diseases provides new ideas and research clues.

Source: Bio Valley

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