Enriched hop extract may help prevent breast cancer
2023-05-13 08:09:47
[Chinese pharmaceutical network technology dynamics] hops extract can help prevent breast cancer? It is reported that researchers from the UIC/NIH Center for Botanical Dietary Supplements Research Center at the University of Illinois at Chicago A new study found that enriched hop extracts activate a chemical detoxification pathway in breast cells that may help prevent breast cancer.
The results of the study were published online June 7, 2016 in the Journal of the American Chemical Society (ACS), Chemical Research in Toxicology, entitled "Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2 -Hydroxylation".
Natural plant dietary supplements such as hops are becoming more popular among women with postmenopausal symptoms because they are considered a safer hormone---associated with increased breast cancer risk Alternative. However, the efficacy and potential toxicity of botanicals are still under investigation.
In this new study, the author of the paper, Judy Bolton, professor of medicinal chemistry and pharmacology at the University of Illinois School of Medicine, and her colleagues added hop extract to two different breast cell lines to observe this extraction. Whether the substance affects estrogen metabolism, and estrogen metabolism is a key mechanism in breast cancer. As a compound in hop extract, 6-prenylnarigenin (6-PN) enhances the detoxification pathway in these mammary cells, and this increased activity of the detoxification pathway is associated with a lower risk of breast cancer.
Bolton said, "We need to explore this possibility further, but our findings suggest that 6-PN may have anticancer effects."
In addition to 6-PN, Bolton and her colleagues also studied 8-prenylnarigenin (8-PN), isoxanthohumol (IX) and xanthohumol (XH) in hops extracts on the mammary gland. The effect of estrogen metabolism in cell lines. According to Bolton, 8-PN only slightly increased estrogen metabolism in both breast cell lines, and the remaining two compounds had no significant effect on either of the two breast cell lines.
Breast cancer is one of the most common cancers diagnosed in women in the United States; approximately one in every eight American women develops invasive breast cancer during her lifetime. According to estimates by the American Cancer Society, the United States is expected to have 246,660 new cases of invasive breast cancer and 61,000 new cases of non-invasive breast cancer this year.
The incidence of breast cancer increased during the 20 years before 2000, but in 2000 it began to decline. From 2002 to 2003 alone, the incidence of breast cancer fell by 7%. Some believe that this decline is partly due to the use of hormone replacement therapy (HRT) after the National Institutes of Health-funded Womens Health Initiative pointed out that HRT is associated with increased breast cancer risk. On the decline. Bolton said it has long been known that estrogen exposure is associated with an increased risk of breast cancer in women after menopause.
The results of the study were published online June 7, 2016 in the Journal of the American Chemical Society (ACS), Chemical Research in Toxicology, entitled "Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2 -Hydroxylation".
Natural plant dietary supplements such as hops are becoming more popular among women with postmenopausal symptoms because they are considered a safer hormone---associated with increased breast cancer risk Alternative. However, the efficacy and potential toxicity of botanicals are still under investigation.
In this new study, the author of the paper, Judy Bolton, professor of medicinal chemistry and pharmacology at the University of Illinois School of Medicine, and her colleagues added hop extract to two different breast cell lines to observe this extraction. Whether the substance affects estrogen metabolism, and estrogen metabolism is a key mechanism in breast cancer. As a compound in hop extract, 6-prenylnarigenin (6-PN) enhances the detoxification pathway in these mammary cells, and this increased activity of the detoxification pathway is associated with a lower risk of breast cancer.
Bolton said, "We need to explore this possibility further, but our findings suggest that 6-PN may have anticancer effects."
In addition to 6-PN, Bolton and her colleagues also studied 8-prenylnarigenin (8-PN), isoxanthohumol (IX) and xanthohumol (XH) in hops extracts on the mammary gland. The effect of estrogen metabolism in cell lines. According to Bolton, 8-PN only slightly increased estrogen metabolism in both breast cell lines, and the remaining two compounds had no significant effect on either of the two breast cell lines.
Breast cancer is one of the most common cancers diagnosed in women in the United States; approximately one in every eight American women develops invasive breast cancer during her lifetime. According to estimates by the American Cancer Society, the United States is expected to have 246,660 new cases of invasive breast cancer and 61,000 new cases of non-invasive breast cancer this year.
The incidence of breast cancer increased during the 20 years before 2000, but in 2000 it began to decline. From 2002 to 2003 alone, the incidence of breast cancer fell by 7%. Some believe that this decline is partly due to the use of hormone replacement therapy (HRT) after the National Institutes of Health-funded Womens Health Initiative pointed out that HRT is associated with increased breast cancer risk. On the decline. Bolton said it has long been known that estrogen exposure is associated with an increased risk of breast cancer in women after menopause.
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