Chinese scientists have developed new algorithms for early diagnosis of cancer
Researchers from China and Australia have recently developed a new algorithm that can help detect the early formation of blood vessels, which may be expected to help early diagnosis of malignant tumors and improve the success rate of patient therapy. The new software (algorithms) developed by researchers can significantly improve the detection of new blood vessels, and we all know that the production of new blood vessels (angiogenesis) can promote the progression of cancer.
Early diagnosis of vascular growth may help researchers quickly detect the growth of malignant tumors, which is a key factor in the success of cancer therapy and the elimination of patient survival. In this study, researchers used a joint study to image the brain and liver of mice at various stages of cancer development. The researchers analyzed high-resolution 3D micro-CT images from 26 mice. Using these images, the researchers developed a powerful algorithm to accurately describe the vascular system of the body. The length and shape formation of blood vessels and their branches can be preserved.
Image taken from: CSIRO
The researchers used a technique called end-point constraints to study the endpoints, which are important for retaining the geometric properties of the neovascular, including the branching pattern and length of the peripheral vessels. Up to now, the acquisition of images of vascular structures by high-resolution imaging has only helped to generate a skeleton map of the vascular structure, which often only provides limited detail and accuracy.
Accurate quantification of the vascular system (especially the number of peripheral vascular branches) plays a key role in the accurate assessment and development of therapies. Anti-angiogenic therapies are often designed to inhibit cancer from producing new blood vessels, and it is often necessary to continuously monitor small changes in blood vessels over time, as patients with anti-angiogenic therapies produce different therapies. The new software developed by the researchers can help determine the small changes that occur during vascular proliferation, including the number and length of blood vessel branches, and also produce a more pronounced vascular system skeleton. Researcher Professor Sanchia Aranda said that the ability of cancer to form cardiovascular is often a key feature of cancer because it promotes the spread of cancer cells to other parts of the body. In this research project, we hope to help us understand the key cancer progression process by helping to study the microenvironment of the tumor through 3D synchroscopic images of blood vessels.
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