Aike Sailong: Using 3D printing technology to remove the surgical blind spot for doctors, allowing patients to enter the personalized era

2018 has passed, and this year's medical equipment is an extraordinary year. At the end of the year, many people are concerned about the uncertainty of policy policies. After 2018, the 4+7 drug purchase boots were put on the ground, and the net purchases swept across the country. We can already confirm that the price reduction and control fees are the keynote. But another trend that is more worthy of attention is the measures that the state is encouraging to innovate.

If the price cut is a big wave of sand, the head is also a knife, the head is also a knife, the coming will always come. Medical device innovation is a long-term heart disease in the development of domestic medical devices. The government has also introduced a number of measures to encourage innovation in medical devices and to achieve import substitution at an early date.

In medical device innovation, 3D printing can be said to be a shot in the heart of domestic medical device development. The development of high-performance medical devices is one of the ten key areas in the 13th Five-Year Plan. The development of personalized medical devices will be at the forefront of high-performance medical device research and development. And 3D printing is a breakthrough in personalized medical devices.

Among the few companies in China that are dedicated to 3D printing medical applications, Aike Cylon focuses on biomedical and human tissue regeneration projects, providing personalized precision surgical solutions. How does Aike Sailong's 3D printing help doctors perform surgery? How to combine 3D printing with personalized medical device research and development? In the "Future Medical Top 100" forum, the arterial network interviewed Zhao Xiaowen, chairman and researcher of Aike Sailong.

Mr. Zhao Xiaowen delivered a speech at the BIN/NGS Frontier Forum of “Top 100 Medical Devices in the Future”

Multidisciplinary background provides pre-operative simulation, intraoperative navigation, postoperative rehabilitation for doctors

When Aike Sailong was first founded, before the professional investors joined, the early investment was all their own funds. Entering the 3D printing industry is not an easy task. To achieve product landing in the 3D printing stage, it is necessary to break through technical limitations, material limitations, and data bottlenecks. However, Aike Cylon still chooses to focus on 3D printing orthopedic consumables, because for orthopedic surgery, 3D printing application is a breakthrough point before, during or after surgery.

At present, Alcoa Dragon has four product lines: including models, navigation panels, personalized implants, and biological stents. 3D printing medical additive manufacturing can be widely used in the clinic, especially in the fields of surgery and skeletal systems. Therefore, the clinical application scenarios of Aike Cylon include, in addition to orthopedics, implantable materials of the cranial and maxillofacial region, plus bio-scaffolds, which can be widely used in regenerative medicine, drug research and development, and new topics. R & D and other areas.

The 3D printing model is mainly used before surgery. It can realize 3D printing personalized surgery model based on MR data, quickly reconstruct 3D model, and print 1:1 simulated bone model with high precision.

For doctors, it is better to communicate with patients and conduct preoperative simulations and exercises. Taking hip replacement surgery as an example, doctors can directly perform key operations such as true sputum search, acetabular rotation center positioning, acetabular measurement and honing, femoral neck osteotomy, femoral canal medullary cavity measurement and femoral osteotomy.

In the past, orthopedic surgeons could only use experience “processing” on a two-dimensional level, but now Axel Dragon can achieve data reconstruction, production of 3D models, and printing of 3D models within 24 hours.

In the operation, Aike Sailong also has a navigational plate solution for interventional surgery. For example, the pedicle screw fixation for the spine can be used to restore the 1:1 spine model based on patient data. The plate can make the contact surface of the spine and the navigation board more conformable, thereby reducing the surgical error and reducing the overall operation cost.

3D printed surgical guides are used in hip replacement surgery. They can also help doctors to quickly determine the positioning of the acetabulum, the size, depth, angle of the burr and the position, angle and length of the acetabular screw during the operation. Surgical plan, reduce surgical injury, shorten operation time, improve the success rate of complex artificial hip replacement, and reduce the failure rate of difficult artificial hip replacement.

The use of the navigation board improves the accuracy of the surgery while reducing the difficulty of orthopedic surgery, and has a large space in complex surgery and grassroots applications.

In terms of personalized implants, it is possible to achieve "private customization" based on patient data.

The process of turning these into reality requires, first of all, a multidisciplinary background and team support. Especially in the medical field, safety and effectiveness are the bottom line that cannot be crossed.

Zhao Xiaowen said to the arterial network: "To truly realize personalized custom additive manufacturing, we need multidisciplinary research in clinical, sports mechanics, biology, anatomy, materials science, etc. Our team covered these in the early stages of construction. In the field, our team is close to 20 researchers. This kind of entrepreneurial team is irreproducible, which also determines that our products and technologies can maintain a certain lead both at home and abroad."

3D printing 2.0 era will be advanced to active organizations

In the field of medical field application, 3D printing has been successfully applied in many cases in China. In Xiangya Hospital, artificial joint replacement surgery combining MR technology and 3D printing technology has also been realized. Applied in medicine, the trend of 3D printing in the medical and health industry can be said to have five stages, from inanimate to simple life features, active tissue, complex tissues and organs, and finally to achieve the printing of a complete life five stages. Although each stage is a successor to the next stage, in fact, every stage requires a huge technological breakthrough.

"Skeletal necrosis is not necessarily the joint spine. It may be caused by trauma or tumor-acquired congenital diseases leading to damage to the skeletal system. After the necrosis, the skeletal system will cause a great loss. The original machining can not do such a complicated structure. It satisfies mechanical strength and simply fixes and connects the damaged or defective part of the bone, but it does not reflect the interaction between the implant and the tissue, that is, affinity, biocompatibility, Especially the hard tissue interface problem.” Zhao Xiaowen said, “So this additive manufacturing can accomplish this mission, to build a complex implant, to create a point and face by adding materials, so that it really realized. Perfect morphological repair and functional reconstruction."

Zhao Xiaowen explained in detail the nature and function of medical additive manufacturing at the "Top 100 Medical Healthcare" conference: "After the implant is implanted into the human body, a foreign body first recruits a large amount of adhesive proteins on the surface to stimulate the signal channel. This signal If the channel is appropriate, it will cause an appropriate inflammatory reaction. If the foreign body causes a large number of inflammatory reactions, a bacterial membrane will form, resulting in the inability to fuse with the tissue, resulting in a clinical use of products with a life expectancy of 10 years. Five years, loose breaks, etc., inflammation can also lead to bone absorption. Therefore, the integration of the surface interface after implantation of the implant can stimulate the regeneration of its own tissue."

And Arcelon is trying to build an organizational level with additive manufacturing. If the 3D printed model is related to anatomy, materials science, and mathematics. Then the analysis at the organizational level involves the interaction of cells and cells, cells and tissues. Only after quantification can the organization be repaired and reconstructed in a targeted manner.

“After the analysis at the organizational level, the personalized implants designed by 3D printing can perform perfect morphological repair and reconstruction of the tissue, especially in the repair of personalized implants in the craniofacial region. The situation is almost blank. There are 20 million cases of craniofacial surgery in the United States. This is the data published by the American Society of Oral and Maxillofacial Surgery. There is no authoritative data in this field in China.” Zhao Xiaowen pointed out the personalization of the craniofacial There are major needs that have not been tapped to fix this area.

At present, Aikesailong has carried out a large number of experimental studies based on the analysis and construction technology of trabecular bone bionic microstructure, using implants made of additive materials, using complex computational simulations to study the quantitative relationship between tissue integration and nutrient transport. . Zhao Xiaowen said: "We restore and analyze different organizations, quantify at the organizational level, and finally carry out bionic design on its lesions. In addition to morphological repair, the interface also has capillary network, and there are new organizations. Cell regeneration, achieving the final fusion between tissues. After 24 months of follow-up, it was found that the growth was good."

Aike Cylon not only has its own interdisciplinary R&D team, but also conducts early research with top universities at home and abroad. In the field of medical additive manufacturing and active materials, Aike Cylon is the world leader.

Aike Sailong has achieved breakthroughs in the field of personalized medical device research and development with 3D printing technology that is launched at the same time. It is expected to realize the technology of 3D printing technology from virtual to reality after digital design model. Aike Sailong was established in 2005. After more than ten years of development, it can also be seen that Aike Sailong is realizing the industrialization of 3D printing.

Zhao Xiaowen also pointed out to the arterial network: "Although there are still many areas worthy of improvement in 3D printing, it can solve many problems and pain points in medical treatment, and there is a lot of room for future development."

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