Zhou Yanheng's group revealed a new mechanism of stem cell-mediated bone metabolism
Release date: 2018-06-14
Recently, Nature Communications published a series of Nature Communication magazines published by Professor Zhou Yanheng of the Department of Orthodontics, Peking University School of Stomatology, entitled "Tet1 and Tet2 maintain mesenchytilization by mediating the demethylation of the P2rX7 promoter. The article "Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter". The article reports a new mechanism by which DNA-modifying enzymes Tet1 and Tet2 regulate osteoporosis and stem cell-mediated bone regeneration, revealing that DNA demethylation abnormalities are an important factor leading to osteoporosis and abnormal bone metabolism.
In China, the incidence of large bone defects in the craniocerebral area caused by periodontal disease, tumor, developmental abnormalities, trauma and other reasons has been high, which has brought a series of effects on the quality of life and mental health of patients. How to effectively achieve bone regeneration and functional recovery of the maxillofacial region and improve the quality of life of patients has always been a difficult problem for dentists. Mesenchymal stem cell-mediated bone regeneration is the key to bone repair, and the molecular mechanism regulating mesenchymal stem cell function plays a major role. DNA modification enzyme Tet mainly modifies the demethylation of human DNA. The balance of bone tissue in human body requires the bidirectional dynamic balance of DNA methylation and DNA demethylation to regulate and precisely control, and plays an important role in regulating stem cell function. As early as three years ago, the research team published a paper on Immunity to reveal a new mechanism for the precise involvement of Tet1 and Tet2 molecules in the regulation of T cells and immune homeostasis. Based on the previous studies, this study is the first to systematically elucidate the new mechanisms by which DNA-modifying enzymes Tet1 and Tet2 regulate mesenchymal stem cells mediated bone homeostasis and bone regeneration, and is effective in preventing and treating osteoporosis and controlling stem cell metabolism abnormalities. The disease provides new ideas and potential targets, and also provides new ideas for the clinical treatment of craniofacial bone defects.
Source: Stomatological Hospital
Whether you're heading back to the gym after the easing of pandemic restrictions or you're continuing to invest in home exercise equipment, online classes or fitness subscriptions, it's a good opportunity to make sure that you have the best tools for muscle recovery in your arsenal to help you reach your fitness goals. To achieve true workout recovery, you'll need a blend of nutrition and physical manipulation, but you can also take advantage of high-tech recovery tools meant to minimize muscle soreness (including the hard-to-resist CBD-infused activewear). If you're looking for a workout tool with science on its side, consider a Massage Gun.
Massage guns use the force of percussive therapy to manipulate your body's soft tissue. They're essentially backed by the same extensive scientific research that supports massage therapy as the optimal tool for sore muscles after a workout. Everyone from recreational gym-goers to professional athletes and people with chronic pain -- they all love these powerful massagers for many reasons.
Percussive therapy is said to help muscles recover faster while reducing muscle pain, muscle fatigue and lactic acid buildup. A percussion gun allows you to focus on a certain muscle group for immediate pain relief. They can also improve your range of motion and flexibility, encourage blood flow, help with muscle stiffness and more. Percussive therapy may even help with stress and sleep. Also, not that you should invest in one for this reason alone, but the slow-motion videos of massage guns punching muscles look insanely Insta-worthy. Just be careful with using one if you have any injuries beyond a muscle ache from a tough workout.
Massagers for Pain Relief,Electric Massagers,Handheld Massagers,Hand Held Electric Massager
Ningbo Shuangtuo International Trade Co., Ltd. , https://www.nbst-sports.com