Science publication reveals the new potential of Rhodiola plants
Science publication reveals the new potential of Rhodiola plants
October 29, 2018 Source: Biological Exploration
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DOI: 10.1126/sciadv.aat6994
Along with aging, more and more people are experiencing memory barriers. A severe memory decline can affect the quality of life and even threaten life safety. To date, no drugs have prevented age-related cognitive decline.
Now, scientists from the Leibniz Institute have for the first time demonstrated that the plant's active ingredient, Rhodiola, can enhance memory.
Rhodiola is a Rosaceae plant that has long been thought to be associated with increased intelligence. In the first article, Birgit Michels and the team tried to identify the specific substances in the plant that can improve memory, because only the key active ingredients were identified, and the possibility of drug development was realized.
Image source: Pixabay
Initially, the research team modeled Drosophila larvae and collaborated with scientists at the International Institute of Plant Biology (IPB) for phytochemical analysis. Finally, they isolated ferulic acid eicosyl ester (FAE-20) and determined that it had an enhanced memory effect.
“While FAE-20 is a simple chemical molecule, identifying it as an active ingredient in plant extracts and correlating it with cognitive abilities is not easy,†said IPB professor Ludger Wessjohann.
Recent studies have found that the addition of FAE-20 to Drosophila foods improves the improvement of 1/3 of the memory of aged fruit flies compared to the control group. At the same time, FAE-20 also prevents age-related proteins from accumulating at synapses. Subsequently, they obtained a similar effect on the mouse model - FAE-20 increased the excitability and memory of CA1 neurons in the hippocampus of the brain.
They found that FAE-20 improves animal memory, whether natural or synthetic. Moreover, synthetic FAE-20 can also partially improve age-related memory decline in adult fruit flies, as well as genetic factors leading to loss of early memory function in young fruit flies.
In summary, at least animal models show that FAE-20 is a compound that helps improve the memory of the elderly. It is worth noting that the use of memory enhancers poses a risk under healthy conditions. Next, scientists will work toward clinical trials to link them to Alzheimer's disease.
Reference materials:
Bioactive compound from the Rhodiola plant improves memory
Memory enhancement by ferulic acid ester across species
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