New mechanism of inflammation promoting tissue regeneration
When it comes to inflammation, people often think of the discomfort that inflammation brings to the body. However, inflammation is essentially a natural, beneficial, and vital response that restores tissue to homeostasis. Researchers from the National Protein Science Center (Beijing) He Fuchu academician team of the Academy of Military Medical Sciences of the Academy of Military Sciences found that apoptotic cells induce inflammatory macrophages to promote repairing microenvironment and promote a new mechanism of tissue regeneration. Relevant research results were published online in the international journal "Journal of the National Academy of Sciences" on the 10th Beijing time.
Researcher Tang Li of the study pointed out that a class of major innate immune cells and macrophages in the inflammatory response play an important role in the maintenance of tissue homeostasis. After the body is stimulated by inflammatory damage, abundant peripheral blood mononuclear cell-derived inflammatory macrophages appear in the tissue. These macrophages are driven by the specific microenvironment of the damaged tissue to promote the regeneration of tissue cells. Macrophages, both roles: both initiate inflammation and promote tissue regeneration and inflammation repair. Therefore, it is important to understand which factors in the microenvironment of inflammatory injury induce the transformation of macrophage characteristics, and to understand the regeneration and repair of tissue damage.
Academician He Fuchu, the author of the study, said that the team's early research independently discovered a novel C-type lectin receptor LSECtin. In this study, they used a mouse model of enteritis to find that LSECtin expressed on intestinal macrophages slowed the progression of intestinal inflammatory injury. They further found that LSECtin acts as a C-type lectin receptor, which promotes macrophage phagocytosis to apoptotic cells in the microenvironment; whereas phagocytosis of apoptotic cells is not a passive event, which can induce intestinal giants in a phagocytic-dependent manner. The phagocytes exhibit pro-repair characteristics that produce protective biological effects.
It is understood that the team's research reveals a new mechanism by which macrophages promote tissue regeneration, while providing new theoretical support for the important scientific issue of "apoptotic cell clearance and tissue homeostasis." (Zhang Qiang)
Source: Technology Daily
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