Dry granulator description
Advantages of dry granulation:
Dry granulation generally does not require the addition of additives. It can directly form dry powder into granules, increase bulk density, improve appearance and fluidity, and control disintegration, facilitate storage and transportation, save energy by wet granulation, and improve wet process. Multiple processes of granules reduce pollution. In addition, the granulation effect of unstable drugs under some hot and humid conditions is more obvious. The scope of application of dry granulation: materials containing crystal water, extracts of traditional Chinese medicine, and materials containing certain moisture (3%-8%) can be granulated by dry granulation, except for a few special materials such as flour, carbon black and graphite. It is difficult to granulate the materials of the class, and it is difficult to granulate the pure Chinese medicine without special treatment. It is possible to consider adding appropriate auxiliary materials; the fineness of the powder is about 80-300 mesh, which is relatively thick or relatively Fine powder has a great influence on dry powder granulation: for coarser powder, granulated granules are not uniform, and for finer powder, there is a certain difficulty in feeding and tableting, which will directly affect the yield of granules.
The yield of dry granulator: The principle of dry granulator is to directly press dry powder into thin slices and then pulverize and granulate. Therefore, the yield of dry granulation is high and low. Firstly, it has a direct relationship with the material formula. The yield of good materials is high; it has a great relationship with the strength of the pressed piece and the structure of the granulation and the speed of the pulverization. The strength and pressure of the tablet and the feeding and tableting speed Related to, the feeding process is also a pre-pressing process and a degassing process. If the air in the material is exhausted as much as possible, and the material has a pre-staying zone, the pressed piece will not be intermittent, so that in other cases, In the case of change, the yield will be relatively increased; the blade structure of the granulation will directly affect the yield of the granules. If the pressed piece is pulverized in the granule box, this will also reduce the yield. The granulating method adopts the rolling type, so that the material is quickly rolled out from the screen, and the yield is improved, and the slower the pulverization speed, the higher the yield of the granules, and the granules are not blocked as much as possible. Point. Domestic standards as long as the yield rate of 30% dry granulator has met the requirements. (Based on starch as standard 20-60 mesh)
Material color change during granulation:
Generally, the color of the material after the dry granulation is different from the original powder. Because the surface area of ​​the powder is larger than the surface area of ​​the granule, the reflection of the light is also different, and the density of the granules after pressing is increased compared with the original powder. The color of the particles will also be deepened. Under normal circumstances, the greater the pressure on the pressure roller, the deeper the color will become. The pressure acting on the pressure roller is not only the pressure of the oil pump, but also the feeding speed and the tableting speed. In the case of a constant pressure and tableting speed, the faster the feeding speed, the greater the pressure acting between the pressure rollers, and vice versa, the slower the pressing speed in the case of a certain pressure and feed speed, acting between the pressure rollers The greater the pressure, the smaller the opposite. Therefore, when using the dry granulator, the user should select a good pressure and speed according to the actual conditions of the material, so as to improve the yield of the product on the basis of ensuring the performance of the product. Dry granulation parameters adjustment problem The dry granulator is suitable for a variety of materials, so the pressure, feeding, tableting, crushing and granulating speed of the dry granulator can be adjusted, so that the requirements for operating the dry granulator are It will be higher. Generally, the manufacturer will provide a relative parameter before leaving the factory. However, in actual use, it should be adjusted according to the material characteristics and the required particle solidity and particle size. Generally, for materials with good fluidity, the feeding speed can be Slower, the pressure on the easy-to-form material can be smaller. For the larger particles, the crushing speed can be slower, as long as the screen mesh is not blocked, other parameters can be changed during the adjustment. In the case, adjust a parameter appropriately to adjust. In short, to adjust the parameters, as long as you grasp the meaning of each parameter, in the actual operation according to the specific circumstances of the adjustment, it is also to continue to test and sum up experience to achieve better results.
Roundness of dry granules:
The roundness of the dry granulated granules is slightly worse than that of the wet granulation, but the roundness of the dry granulation has a certain relationship with the thickness of the slab and the form of the granulating blade (except for the material itself) Change the thickness of the sheet to increase the roundness of the particles. Generally, the thickness of the pressed sheet can be appropriately adjusted according to the particle size, so that the roundness of the particles after the whole grain is better, and the structure of the whole knife can be improved. Improve the roundness of the particles. In short, I hope that before choosing a dry granulator, the customer can send us some materials. Let's do some experiment to see if the particles can meet the needs of the customers, because each material will have different formulas. As a result, customers are able to choose the right equipment.
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