Chinese scholars take the lead in developing new technologies to provide a new method for accurate tumor diagnosis
Fudan University revealed on the 7th that Zhang Fan, a professor of chemistry at the school, proposed the application of near-infrared fluorescence lifetime imaging technology to multiple detection of living organisms. This is a completely new technology that enables non-invasive diagnosis of tumors without the need for surgical slicing.
It is understood that at present, sectioning tissue is the main method for diagnosing tumors in clinical medicine. However, this diagnostic method relies on the naked eye to judge the nature, size and stage of the tumor, and the accuracy of the result cannot be completely guaranteed, so there are many risks and hidden dangers. At the same time, the traditional slice biopsy process is also difficult to avoid the risk of tumor cell metastasis.
According to reports, fluorescence is a common luminescence phenomenon in nature, and the biological tissue can be imaged and detected by a fluorescent probe medium. The advantages of fluorescence imaging make it a promising application in life sciences, pharmacy and medical diagnostics. It is reported that the research results of Zhang Fan's team are published online in the journal Nature Nanotechnology. At the same time, "Nature·Nanotechnology" also published "views and news", and featured news reports and comments on the research results.
Zhang Fan said that in response to the problems in previous research, the team proposed a "multiple imaging method based on time dimension". In the experiment, the researchers found that the fluorescence lifetime value has good stability and does not change due to the change of biological tissue depth. According to reports, the researchers successfully applied this new imaging technology to the accurate diagnosis of breast cancer tumors. The quantitative detection results of multiple tumor markers are highly consistent with the results obtained by clinical medical traditional detection techniques.
Compared with the traditional clinical diagnosis technology can only limit the detection of one tumor marker at a time, the time dimension imaging method proposed by Zhang Fan team can simultaneously quantify multiple tumor markers, which significantly improves the detection efficiency.
According to reports, the time dimension imaging method also replaces the original biopsy operation in the form of “photographingâ€, which not only directly avoids the risk of tumor cell metastasis, but also reduces the human error that may be caused by traditional methods in tissue sectioning, processing and scoring. Judging risk, it is expected to become a new type of non-invasive tumor diagnosis method.
Zhang Fan told reporters that in the follow-up study, the research team will analyze and investigate the distribution and metabolism of fluorescent lifetime nanoprobes in various organs after entering the human body. (Reporter Chen Jing)
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