Adapalene Anti-Acne Skin Mild Moderate Acne Pure Adapalene 106685-40-9
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Name: Adapalene
Adapalene CAS: 106685-40-9
Adapalene MF: C28H28O3
Adapalene MW: 412.52
Adapalene Chemical Properties: White Crystalline Solid
Adapalene Assay: 99.5%
Adapalene Usage: Retinoid selective for retinoic acid receptor (RAR) subtypes β and γ. Antiacne.Â
Biological Activity: Retinoic acid analog that is a RAR β and RAR γ agonist (AC 50 values are 2.2, 9.3, 22 and > 1000 nM for RAR β, RAR γ, RAR α and RXR α receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.Â
Packing: Foil bag
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Application of Adapalene:
It stimulates cell division in the skin and reduces the production of keratin. It aids skin peeling and prevents the formation of acne lesions (comedones). The action of adapalene combats the changes that take place in acne.
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Adapalene is used in the treatment of mild to moderate acne. It is best suited to dry and fair skin.
Adapalene Powder is a white to off-white powder, which is soluble in tetrahydrofuran, very slightly soluble in ethanol, and practically insoluble in water. Adapalene has actions similar to vitamin A (retinol).Â
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Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. It is effective against acne conditions where comedones are predominant.
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Adapalene COA:
| Test Item | Specifications | Result |
| Description | Â | |
| Appearance | Off white or white white crystalline powder |
white crystalline powder |
| Identification | By infrared spectrum | Conforms |
|  | By HPLC |  |
| Melting Range | 319-322ºC | 320-322ºC |
| Residual Solvent | DMA≤ 0.109 | ≤0.01 |
|  | HAc≤0.5% | ≤0.01 |
| Partical Size | ≤50um | ≤50um |
| Related Substances | Total Impurities:NMT 0.5% | 0.003 |
|  | Single Impurity:NMT 0.1% | 0.0008 |
| Assay | NLTÂ 99.50% | 0.9956 |
| Heavy metals | NMT 20 ppm | Conforms |
| Loss On Drying | NMT 0.5% | 0.0034 |
| Residue on Ignition | NMT 0.1% | 0.0007 |
| Chloride | NMTÂ 0.02% | <0.02% |
| Vitriol | NMTÂ 0.02% | <0.02% |
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Name: Adapalene
Adapalene CAS: 106685-40-9
Adapalene MF: C28H28O3
Adapalene MW: 412.52
Adapalene Chemical Properties: White Crystalline Solid
Adapalene Assay: 99.5%
Adapalene Usage: Retinoid selective for retinoic acid receptor (RAR) subtypes β and γ. Antiacne.Â
Biological Activity: Retinoic acid analog that is a RAR β and RAR γ agonist (AC 50 values are 2.2, 9.3, 22 and > 1000 nM for RAR β, RAR γ, RAR α and RXR α receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.Â
Packing: Foil bag
Â
Application of Adapalene:
It stimulates cell division in the skin and reduces the production of keratin. It aids skin peeling and prevents the formation of acne lesions (comedones). The action of adapalene combats the changes that take place in acne.
Â
Adapalene is used in the treatment of mild to moderate acne. It is best suited to dry and fair skin.
Adapalene Powder is a white to off-white powder, which is soluble in tetrahydrofuran, very slightly soluble in ethanol, and practically insoluble in water. Adapalene has actions similar to vitamin A (retinol).Â
Â
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. It is effective against acne conditions where comedones are predominant.
Â
Adapalene COA:
| Test Item | Specifications | Result |
| Description | Â | |
| Appearance | Off white or white white crystalline powder |
white crystalline powder |
| Identification | By infrared spectrum | Conforms |
|  | By HPLC |  |
| Melting Range | 319-322ºC | 320-322ºC |
| Residual Solvent | DMA≤ 0.109 | ≤0.01 |
|  | HAc≤0.5% | ≤0.01 |
| Partical Size | ≤50um | ≤50um |
| Related Substances | Total Impurities:NMT 0.5% | 0.003 |
|  | Single Impurity:NMT 0.1% | 0.0008 |
| Assay | NLTÂ 99.50% | 0.9956 |
| Heavy metals | NMT 20 ppm | Conforms |
| Loss On Drying | NMT 0.5% | 0.0034 |
| Residue on Ignition | NMT 0.1% | 0.0007 |
| Chloride | NMTÂ 0.02% | <0.02% |
| Vitriol | NMTÂ 0.02% | <0.02% |
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